Formed in 1996 the regiment is responsible for helicopter operations in southern Italy and on the islands of Sicily and Sardinia.

[6] The 2nd Army Aviation Regiment was named for Sirius (Italian: Sirio), which is the brightest star in the Canis Major constellation.

[6] On 18 September 1996, the President of the Italian Republic Oscar Luigi Scalfaro granted the regiment a flag, which since then has been decorated with one Silver Medal of Army Valor, that was awarded to the then autonomous 20th Army Light Aviation Squadrons Group "Andromeda" for its service after the 1980 Irpinia earthquake.

On the same date, the regiment was transferred from the Southern Military Region to the 2nd Defense Forces Command in Naples.

On 31 July 2002, the 21st Squadrons Group "Orsa Maggiore" was transferred from the 2nd Air Cavalry Regiment "Sirio" to the Army Aviation Training Center.

[4][5][8] On 24 June 2013, the 21st Squadrons Group "Orsa Maggiore" returned from the Army Aviation Training Center to the regiment.