The Dnepr Regiment of Pikemen fought in the Russo-Turkish War of 1768–1774 from 1769, participating in the final assault of the siege of Bender [ru] on 16 September 1770 and the campaign of Pyotr Rumyantsev on the right bank of the Danube in 1771.

[1][3] From 1810 to 1814 Colonel Spiridon Zhevakhov served as regimental commander; he was promoted to Major General on 15 September 1813.

[1] At the beginning of the 1812 French invasion of Russia, the active squadrons of the regiment, numbering 1,116 men, were part of the Sergei Kamensky's corps in the Third Reserve Army of Observation, positioned in Volhynia.

Subsequently, as part of Chaplits' detachment, the regiment distinguished itself in the Slonim affair and fought in the Battle of Berezina.

[1] The Pavlograd Hussars fought in the Russo-Turkish War of 1828–1829, besieging Silistra and fighting in the Battle of Kulevicha.

[3] To suppress the Hungarian Revolution of 1848, the regiment was sent to Hungary as part of the detachment of General Mikhail Cheodayev [ru].

During the Crimean War, the regiment fought in actions at Giurgiu and Slobozia in the initial occupation of the Danubian Principalities.

In the same year it fought in the suppression of the Polish January Uprising, participating in fighting in what became Łomża Governorate.

In honor of its centenary, the regiment received a new St. George standard on 9 July, with the added inscription 1764–1864 and Alexander jubilee ribbon.

[1] In Leo Tolstoy's novel War and Peace characters Nikolai Rostov and Vasily Denisov are depicted as officers in the regiment.