The 2nd Tennessee Infantry was organized at Camp Dick Robinson in Garrard County, Kentucky and at Somerset, Kentucky and mustered in for a three-year enlistment on September 28, 1861.
The regiment was attached to George H. Thomas' Command, Army of the Ohio, to November 1861.
3rd Brigade, District of West Virginia, Department of the Ohio, to November 1862.
1st Brigade, 2nd Division, Center, XIV Corps, Army of the Cumberland, to January 1863.
2nd Brigade, District of Central Kentucky, Department of the Ohio, to June 1863.
1st Brigade, 1st Division, XXIII Corps, Department of the Ohio, to August 1863.
1st Brigade, 2nd Division, Cavalry Corps, Department of the Ohio, to April 1864.
2nd Brigade, 4th Division, District of East Tennessee, to August 1865.
Skirmishes at Big Creek Gap and Jacksborough March 14 (Company B).
Operations at Rogers and Big Creek Gaps September 10.
Evacuation of Cumberland Gap and retreat to Greenupsburg, Ky., September 17-October 3.
Ordered to Louisville, Ky., Cincinnati, Ohio, and thence to Nashville, Tenn. Duty there until January 1863.
Burnside's Campaign in eastern Tennessee August 1863 to February 1864.
Defense of Cumberland Gap during siege of Knoxville November 17-December 5.
Operations about Dandridge and Mossy Creek December 24–28.
Ordered to Cumberland Gap March 16, and duty there until August.