The 2nd Regiment of Riflemen was a unit of the U.S. Army in the early nineteenth century.

[1]: 142 The regiment spent virtually its entire life on garrison duty in Detroit, Michigan Territory and Fort Malden, Upper Canada after Detroit had been abandoned by the British following the Battle of Lake Erie.

Regimental depots were placed in Chillicothe, Ohio; Nashville, Tennessee, and Lexington, Kentucky.

The regiment suffered continuing shortages of uniforms and equipment.

The riflemen did ensure that trade with Native Americans was fair and that civil order was maintained.