It was one of four Swiss regiments integrated into the Grande Armée during the Napoleonic Wars.

[2] In August 1807, the regiment was sent to the Gironde Observation Corps [fr], which would participate in the invasion of Portugal.

[2] The regiment took part in the battles of Ostrovno, Vitebsk, Smolensk, Dorogobuzh and Borodino.

[2] On 2 April 1815, following Napoleon's return to power, the four regiments were dissolved and the 2nd (Swiss) Foreign Regiment was formed with Swiss soldiers who remained loyal to the Emperor; it participated in the Battle of Waterloo on 18 June 1815.

The general staff consisted of 54 men, but the post of major remained vacant.