In 1951, the 308th was activated as a bombardment unit at Hunter Air Force Base, Savannah, Georgia, and initially equipped with Boeing B-29 Superfortresses.

Those aircraft were then replaced with new Boeing B-47E Stratojet swept-wing medium jet bombers in 1954, capable of flying at high subsonic speeds and primarily designed for penetrating the airspace of the Soviet Union.

It was tasked to design, develop, field and maintain a family of air-to-ground munitions that enhanced United States armed forces strike capabilities.

The mission of the 308th Armament Systems Wing was to enhance worldwide Air Force combat capability, effectiveness, aircrew survivability, and readiness through joint development, procurement, deployment and sustainment.

The 308th designed, developed, produced, fielded, and sustained a family of air-to-ground and air-to-air munitions, enhancing warfighter capabilities (both U.S. and allies) in defeating a spectrum of enemy targets.

The wing consisted of over 400 highly qualified personnel trained in the development, test, acquisition, fielding, and operational support of systems such as the Joint Direct Attack Munition , Joint Air-to-Surface Standoff Missile, Small Diameter Bomb, Sensor Fused Weapon, Wind Corrected Munitions Dispenser and a host of other specialized programs.