During World War II, the 322d Troop Carrier Wing primarily carried high priority cargo destined for Air Corps organizations in the Southwest Pacific Area (SWPA).

Almost immediately after it commenced operations in Europe, the 322d became involved in a major airlift of French troops (Project Bali Hai) from bases in France to Indochina.

In addition to its routine duties, the division supported numerous humanitarian missions to Turkey, Iran, Morocco, and Pakistan, among other states.

It also assumed responsibility for all aeromedical operations and administrative airlift in the theater, including highly positioned military and civilian U.S. and foreign government officials.

In addition, the division supported military exercises such as Ardent Ground, Dawn Patrol, Flintlock, and Cold Fire/Reforger.