It was converted into a tank destroyer battalion after the United States entered World War II.

On 10 December 1931, the 322nd's Minnesota units were inactivated and the entire regiment was simultaneously moved to Des Moines.

[4] After the United States entered World War II, the regiment was converted into the 73rd Tank Destroyer Battalion on 30 January 1942.

[3] On 31 January 1971, it was reconstituted in the Army Reserve, represented by 1st Squadron, 322nd Cavalry, which was assigned to the 89th Division (Training) and activated at Omaha, Nebraska.

The distinctive unit insignia consisted of a gold colored metal and enamel device 1 1/16 (2.70 cm) in diameter with a spear-brandishing Sioux warrior wearing a war bonnet on horseback.

The coat of arms was of a similar design except that it omitted the motto and included the Organized Reserve Minuteman crest above the shield.