During the Cuban Missile Crisis, the squadron was deployed to McCoy Air Force Base, Florida, ready to react at a moments notice for possible combat over Cuba.

The squadron was deployed to Thailand in late 1965 to Korat Royal Thai Air Force Base for combat operations over Southeast Asia.

However, the 333d then transferred to Takhli Royal Thai Air Force Base to relieve the 335th Tactical Fighter Squadron.

Took part in routine deployments and training operations with the A-7D until 1976, being upgraded to the new Fairchild Republic A-10A Thunderbolt II, becoming the first tactical unit to fly the A-10A.

Trained and deployed with the 355th Wing until inactivated in February 1991 as part of the drawdown of the Air Force after the Cold War ended.