After training with Douglas A-20 Havocs in the United States the squadron deployed to the European Theater of World War II, where it engaged in combat until the Surrender of Germany.

[2] The squadron deployed to the European Theater of Operations in March 1944, where it became part of IX Bomber Command of Ninth Air Force.

After D-Day, the squadron supported ground forces during the Battle of Normandy by hitting gun batteries, rail lines, bridges, communications, and other objectives.

During July 1944, it aided the Allied offensive at Caen and the breakthrough at Saint-Lô with attacks on enemy troops, flak positions, fortified villages, and supply dumps.

The 341st provided refueling support for SAC wings deploying and redeploying from Europe and North Africa during Operation Reflex.

During October and November 1962 the 341st temporarily curtailed training and assumed an increased alert posture in response to the Cuban Missile Crisis.