345 Park Avenue is a 634-foot (193 m) skyscraper in the Midtown Manhattan neighborhood of New York City.

Completed in 1969, with 44 floors, the building was designed by Emery Roth & Sons.

[4] It is near the Racquet and Tennis Club and Park Avenue Plaza to the northeast; the Seagram Building to the north; 599 Lexington Avenue to the northeast; and St. Bartholomew's Episcopal Church and the General Electric Building to the south.

It was sold to Sheraton Hotels in 1958 and renamed the Sheraton-East.

Exteriors of 345 Park Avenue were used as the headquarters of CSC and Continental Corp. in the Aaron Sorkin series Sports Night from 1998 to 2000.