It served in combat in the European Theater of Operations, where it earned a Distinguished Unit Citation and the French Croix de Guerre with Palm for its actions.

[7] As a result, the squadron only began organizing in October 1942, when the initial cadre of the ground echelon (4 officers and 27 enlisted men) were assigned after it had moved to Gowen Field, Idaho.

[10] The 350th completed its training and departed Kearney Army Air Field, Nebraska for the European Theater of Operations on 1 May 1943.

On 17 August 1943, it participated in an attack on a factory manufacturing Messerschmitt Bf 109 fighters in Regensburg, Germany, which seriously disrupted production of that plane.

Unknown to AAF intelligence at the time, the attack also destroyed almost all of the fuselage construction equipment for Germany's secret Me 262 jet fighter.

[16][d] Two days later, German fighters shot down the leader of the 45th Combat Bombardment Wing, and the 100th Group took the lead in another attack on Berlin.

In August and September it supported Operation Cobra, the breakout at Saint Lo, and bombed enemy positions in Brest.

As Allied forces drove across Northern France toward the Siegfried Line in October and November, it attacked transportation and ground defenses.

[2] Starting with the Regensburg mission of August 1943, the squadrons of the 100th Bombardment Group began suffering losses among the highest in VIII Bomber Command.

[21][e] Its highest one day loss occurred on the 6 March 1944 attack on Berlin, when 15 bombers failed to return, ten from the 350th Bombardment Squadron.

The 350th also provided cargo support and intratheater refueling during combat in Southwest Asia from August 1990 – March 1991 during the Gulf War.

[2] At the end of the Cold War, the Air Force underwent extensive changes as a result of several rounds of Base Realignment and Closure (BRAC).

In 1997, the Republic of Singapore Air Force (RSAF) selected McConnell as its training base for its KC-135 crews and maintenance personnel.

Before the end of the year, McConnell tankers were sent to the Middle East, Central Asia, Horn of Africa, and other locations to provide air refueling support during Operation Enduring Freedom.

Beginning in 2003, the 22nd ARW took an active role in Operation Iraqi Freedom as tanker crews deployed to the Arabian Peninsula.