The squadron was equipped with the LGM-25C Titan II intercontinental ballistic missile (ICBM), with a mission of nuclear deterrence.

The squadron was responsible for Launch Complex 374–7, site of the 1980 explosion of a Titan II ICBM in Damascus, Arkansas.

[2][3] As the squadron was forming and beginning its training in Consolidated B-24 Liberators, at Alamogordo Army Air Field, New Mexico in August 1942, almost all its personnel were transferred to the 330th Bombardment Group.

In order to prepare for and sustain combat operations in China, the squadron had to conduct numerous flights over the Hump transporting gasoline, lubricants, ordnance, spare parts and the other items it needed.

The 374th supported Chinese ground forces and attacked airfields, coal yards, docks, oil refineries and fuel dumps in French Indochina.

[3] On 26 October 1944, Major Horace S. Carswell, the squadron's operations officer, attacked a Japanese convoy in the South China Sea, meeting with heavy antiaircraft fire, badly damaging his plane.

[6] It was reactivated a few months later in October with new B-47E Stratojet swept-wing medium bombers, which were capable of flying at high subsonic speeds and primarily designed for penetrating the airspace of the Soviet Union.

The 1980 Damascus Titan missile explosion is a 'Broken Arrow' incident occurred at site 374–7 on 19 September 1980 which killed one airman and injured twenty-one personnel in the immediate vicinity (see below).

On 18 September 1980 at Titan II Launch Complex 374–7, a 308th Missile Maintenance Squadron airman was adding pressure to the second stage oxidizer tank.

Eventually, the crew evacuated the launch control center as military and civilian response teams arrived to tackle the hazardous situation.

During the recovery, the Missile Wing Commander received strong support from other military units as well as Federal, state, and local officials.

Arkansas's governor, Bill Clinton, played an important role in overseeing the proper deployment of state emergency resources.

Perhaps realizing the public confidence had suffered a blow, wing personnel made a stronger effort to reach out to local communities.

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