And it provides support for U.S. host units—making possible the command and control of the United States' entire military transportation effort.

After a period of intensive training, now as a wing, it participated in troop carrier and airlift operations, paratroop drops, and other exercises, October 1950 – July 1952.

It conducted domestic aeromedical airlift and evacuation operations in the continental United States, Alaska, and off-shore areas of the North Atlantic and the Caribbean from January 1966 for the Air Force, other Department of Defense agencies, the U.S. Public Health Service, and the Veterans Administration (VA), augmented by aircraft of the Air National Guard and other Military Airlift Command units.

Between January 1966 and April 1975 the wing maintained and scheduled support aircraft at Scott Air Force Base, Illinois, generally using aircrews provided by other Scott-based units to provide scheduled air shuttle and courier service to the east and west coasts.

The wing operated and maintained an aeromedical evacuation system on a rotational basis in Southwest Asia, September 1990 – April 1991.