It engaged in combat, primarily in China and Southeast Asia until June 1945, when it assumed a mainly transport role.

[2][3] As the squadron was forming and beginning its training in Consolidated B-24 Liberators, at Alamogordo Army Air Field, New Mexico in August 1942, almost all its personnel were transferred to the 330th Bombardment Group.

In order to prepare for and sustain combat operations in China, the squadron had to conduct numerous flights over the Hump transporting gasoline, lubricants, ordnance, spare parts and the other items it needed.

The 375th supported Chinese ground forces and attacked airfields, coal yards, docks, oil refineries and fuel dumps in French Indochina.

It attacked shipping, mined rivers and ports and bombed maintenance shops and docks at Rangoon, Burma and attacked Japanese shipping in the East China Sea, Formosa Straits, South China Sea and Gulf of Tonkin.

[1][5] It was reactivated a few months later in October as the 375th Bombardment Squadron with new Boeing B-47E Stratojet swept-wing medium bombers, capable of flying at high subsonic speeds and primarily designed for penetrating the airspace of the Soviet Union.

This article incorporates public domain material from the Air Force Historical Research Agency