The unit served as a reserve regiment until it was called to active duty during World War II, whereupon it saw action in the Pacific theater as part of the 96th Infantry Division.

The 382nd Infantry Regiment was first constituted on 5 September 1918, in the National Army and assigned to the 96th Division.

[1] Per the National Defense Act of 1920, the 382nd Infantry was reconstituted in the Organized Reserve on 24 June 1921, assigned to the 96th Division, and allotted to the Ninth Corps Area.

Re-designated on 17 October 1999, as the 382nd Regiment, the unit was reorganized to consist of the 1st, 2nd, and 3rd Battalions, elements of the 75th Division (Training Support).

[1] Three men earned the U.S. military's highest decoration, the Medal of Honor, while serving with the 382nd Infantry.