Its last assignment was with the 13th Strategic Missile Division at Francis E. Warren Air Force Base, Wyoming, where it was inactivated on 25 March 1965.

The wing was first active during World War II as the 389th Bombardment Group, a Consolidated B-24 Liberator unit that served with VIII Bomber Command in England.

The group received a Distinguished Unit Citation for the detachment's participation in Operation Tidal Wave, the 1943 low-level attack against oil refineries at Ploiești, Rumania on 1 August 1943.

Refusing to turn back although gasoline was streaming from his flak-damaged plane, Lt Hughes flew at low altitude over the blazing target area and bombed the objective.

[3] The 389th resumed operations from England in October 1943 the group concentrated primarily on strategic objectives in France, the Low Countries, and Germany.

Targets struck by the group included shipyards at Vegesack, industrial areas of Berlin, oil facilities at Merseburg, factories at Münster, rail yards at Sangerhausen, and V-weapon sites in the Pas de Calais.

It struck enemy positions to aid the breakthrough at St Lo in July 1944, hit storage depots and communications centers during the Battle of the Bulge from December 1944 – January 1945 and dropped food, ammunition, gasoline, and other supplies to troops participating in the Operation Varsity.

389th Bombardment Group 389th Strategic Missile Wing This article incorporates public domain material from the Air Force Historical Research Agency