It was her last work, first staged at the Royal Court's Jerwood Theatre Upstairs on 23 June 2000, directed by James Macdonald, nearly one and a half years after Kane's death on 20 February 1999.
The production starred Polish film actress Magdalena Cielecka and featured a number of other performers from TR Warszawa in supporting roles.
[3] In 2003, there was a successful staging in Brazil, which played to a full house for six consecutive months in São Paulo, and also gained media attention for its defying gender aspect, as the role was performed by male actor Luiz Päetow.
"[6] Charles Spencer of the Telegraph said "it is impossible not to view it as a deeply personal howl of pain.”[7] David Greig considered the play to be "perhaps uniquely painful in that it appears to have been written in the almost certain knowledge that it would be performed posthumously.
"[1] An operatic adaptation of 4.48 Psychosis, commissioned by Royal Opera and written by British composer Philip Venables, was staged at the Lyric Hammersmith in 2016.