It was included in the evacuation of Sinai under the Camp David peace agreement with Egypt, moving to the lower Jordan Valley.

One of the brigade's battalions took part in the Sultan Yaakub engagement, making it all the way to the Beirut-Damascus highway.

The brigade fought mostly in the Eastern zone, by the villages of Markabeh, Bint Jbeil and the Salooky Valley.

The 401st Brigade lost 12 soldiers in battle, with four killed after their Puma armored engineering vehicle was struck.

IVm tanks of 401st Brigade (IDF) killed between 120 and 130 Hamas militants during the ground fighting phase of Operation Protective Edge.

[2] The 52nd Battalion of the 401st Brigade was involved in combat near Zikim on 10 October 2023, according to a video posted on social media by the IDF.