As of 2022, the wing had forward deployed units in six locations in West and East Africa.

[3][4][5] On 9 June 2023, the wing was inactivated during a ceremony at Ramstein Air Base, with its components becoming part of the 406th Air Expeditionary Wing, which was activated at Ramstein the same day.

[6] Among the missions conducted or supported by the unit were medical evacuation, logistics support, ISR and aerial refueling.

For its ISR mission, the wing utilizes MQ-9 Reaper drones, having the US Air Force's only active-duty MQ-9 unit deployed to the region under its command.

[2] As of 2022, the 435th Air Expeditionary Wing was made up of two groups, which in turn consisted of ten squadrons:[3] This United States Air Force article is a stub.