The 44 FG is an associate unit of the active duty 325th Fighter Wing (325 FW) of the Air Combat Command (ACC).

Otherwise, the 44 FG operates as a geographically separated unit (GSU) of AFRC's 301st Fighter Wing (301 FW) at NAS JRB Fort Worth, Texas.

The group also supported Northrop T-38 Talon operations at Holloman AFB in which they played the role of adversary aircraft in F-22 training exercises.

During same period, the 44 BG took part in anti-submarine patrols over the Gulf of Mexico and was credited with the destruction of one German Kriegsmarine U-boat.

The air echelon was based at Grenier Field, New Hampshire and remained there until the first aircraft left for the United Kingdom late in September 1942.

The 44th Bomb Group's operations consisted primarily of assaults against strategic targets in France, Belgium, the Netherlands, Germany, Italy, Romania, Austria, Poland, and Sicily.

Among the targets attacked were submarine installations, industrial establishments, airfields, harbors, shipyards, and other objectives, November 1942 – June 1943.

Late in June 1943, a large detachment moved to North Africa to help facilitate the Allied invasion of Sicily by bombing airfields and marshalling yards in Italy.

Before returning to England at the end of August, the detachment bombed an aircraft factory in Austria and supported ground forces in Sicily.

This proved to be the 44th's last detachment and in October when several new B-24 groups were arriving in Norfolk in the United Kingdom, the 44th was fully committed to the combined bomber offensive from the UK.

From November 1943 to April 1945, the group carried out operations against targets in western Europe, concentrating on airfields, oil installations, and marshalling yards.

The group took part in the intensive campaign of heavy bombers against the German aircraft industry during Big Week, 20–25 February 1944.

The group attacked airfields and transportation in support of the advance into Germany, and flew a resupply mission during the airborne assault across the Rhine in March 1945.

During the course of hostilities, the 44 BG flew a total of 343 missions and its gunners were credited with 330 enemy fighters shot down and its own losses, the highest of any B-24 group in the Eighth Air Force, were 153.

Removal of the first Minuteman II missile assigned to the 44 OG occurred at Site G-02, near Red Owl, South Dakota, on 3 December 1991.

On 1 June 1992, the 44 OG was relieved of its Emergency War Order mission and its primary focus was deactivation of the Minuteman II weapon system.

On 1 July 1993 its parent unit, the 44 MW changed hands from ACC to the Air Force Space Command (AFSPC) along with all other ICBM wings.