The 45th Pennsylvania Volunteer Infantry was an infantry regiment that served in the Union Army during the American Civil War.

The 45th Pennsylvania Infantry was organized beginning July 28, 1861 and mustered in October 21, 1861 at Camp Curtin in Harrisburg, Pennsylvania for a three-year enlistment under the command of Colonel Thomas Welsh.

[1] The 45th Pennsylvania Infantry mustered out July 17, 1865.

Attached to: The official list of battles in which the regiment bore a part:[3] (NOTE — Battles are Bolded, Italicized; campaigns are Italicized) The regiment lost a total of 479 men during service; 13 officers and 214 enlisted men killed or mortally wounded, 252 enlisted men died of disease.

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