The unit was formed as a battalion in 1957 and operated the army's telecommunications network in the Apulia, Basilicata, Calabria, Campania and Molise regions.

On 12 November 1976, the President of the Italian Republic Giovanni Leone granted with decree 846 the battalion a flag.

On 1 June of the same year, the 2nd TLC Infrastructure Managing Company moved from Bari to San Giorgio a Cremano.

The newly formed regiment continued to operate the army's telecommunications network in southern Italy.

[1] On 4 May 1998, the battalion's command and the 2nd TLC Infrastructure Managing Company moved from San Giorgio a Cremano to Nocera Inferiore.

Since then the 46th Signal Regiment operates the army's telecommunications network in all of southern Italy and on Sicily.