[5] It was discovered by Max Wolf and Luigi Carnera on January 17, 1901, and was assigned the provisional designation 1901 FX.
[9] In 1992 a simple check of 466 Tisiphone's position was made by the Association of Lunar and Planetary Observers (ALPO).
In 1997 Tisiphone was studied by Worman and Christianson at the Feder Observatory located near Minnesota State University, Moorhead, with the goal of determining its rotational period.
[4] In 2001 Lagerkvist et al. published their results on a study of the Cybele asteroid family, which includes 466 Tisiphone.
Relative photometric observations of Tisiphone were carried out in 1998 and 1999 using the 1.2 m telescope at the Calar Alto Observatory located at the Max-Planck-Institut für Astronomie in Heidelberg, Germany.