The regiment traces its lineage back to the 47th Separate Battalion of the VNOS (Air Observation, Warning, and Communications Service), formed at Stary Petergof as part of the Leningrad air defense system in November and December 1940.

The battalion helped defend Leningrad during the siege of the city in World War II, and in the early postwar years became a radio-technical unit.

In the spring of 1967, the brigade relocated to Khvoyny, providing radar capabilities to the 6th Independent Air Defense Army.

[2] In 2009, the 46th Brigade became the 333rd Radio-Technical Regiment as part of the reform of the Russian Armed Forces.

[4] In November 2016, a conscript assigned to the regiment departed unauthorized without his weapon.