The 4735th was formed in 1957 to provide a single command and support organization for the two fighter interceptor squadrons of Air Defense Command (ADC) at Otis when the 33rd Fighter Wing inactivated and the 551st Airborne Early Warning and Control Wing became the host at Otis.

[7] All models were equipped with data link for interception control through the Semi-Automatic Ground Environment system.

[10] In February 1959, the 60th FIS converted to McDonnell F-101 Voodoo aircraft, becoming the first F-101 squadron in Air Defense Command.

[7] The 4735th was discontinued on 1 August 1959 when the 58th FIS relocated to Walker Air Force Base, New Mexico, leaving only one operational fighter squadron at Otis.

[10] This article incorporates public domain material from the Air Force Historical Research Agency