[1] The alliance was launched in 2017 by Charles University, along with the University of Heidelberg, Sorbonne University and the University of Warsaw;[2] the official founding act took place on March 10, 2018, with the signing of a joint declaration in Paris.

On February 28, 2019, Alliance 4EU + and 53 other university alliances submitted an application for funding under the “European Universities” call of the European Erasmus+ program.

[7][8] The University of Geneva joined the alliance in August 2022.

Alliance 4EU+ aims to develop cooperation in the fields of training and education, research and administration, as well as an infrastructure that seamlessly brings together students, teachers, researchers and administrative staff.

[2] Four multidisciplinary flagship programs have been adopted: Alliance members are prestigious public universities in six European countries, in four regions for which the European Union has adopted macro-regional strategies (Adriatic-Ionian region, Alpine region, Baltic Sea region, Danube region):