501 Züm Queen shares routing with York Region Transit's Viva Orange bus rapid transit route between Martin Grove Road and Vaughan Metropolitan Centre, and has been fare integrated with it since its creation.

Originally, the route continued to York University (which also had a subway connection when the line's extension to Vaughan opened on December 17, 2017).

These two branches were suspended during the COVID-19 pandemic,[2] with the 501C being reinstated on September 6, 2022, and the 501 being cut back to Vaughan Metropolitan Centre station.

[3] On June 24, 2024, the 501C branch was cancelled permanently, leaving only the base route operating.

[4] Brampton Transit cited high operating costs due to Highway 407 tolls and the recently introduced fare integration program (enabling free transfers from the TTC subway) as reasons for the change.