(Coxwell Avenue is part of a jog that separates the upper and lower portions of Gerrard Street.)

Streetcar service is provided 24 hours per day on most portions of the route.

There were several versions of the Carlton route starting from August 1886 when the Toronto Street Railway created a horsecar line of that name.

In 1923, College Street terminated at Lansdowne Avenue; thus, the tracks for the Carlton route needed to turn south for one short block on Lansdowne Avenue to join the tracks on Dundas Street West.

Carlton streetcars started using the new loop before the subway platforms were open to the public on May 10, 1968.

[8][9] By November 24, 2019, CLRVs were no longer being scheduled for 506 Carlton, having been replaced by Flexity Outlook streetcars, thus making the route fully accessible.

[10][11] From late June 2020 until the end of 2020, regular streetcar service along the entire 506 Carlton line was temporarily replaced by buses to accommodate several construction projects,[12][13] including the modification of the streetcar overhead between Bay Street and High Park for pantograph use.