50 Biscayne is a fifty-seven story skyscraper condo in the Central Business District of Downtown Miami, Florida, United States.

The tower is 554 feet (169 m) tall and contains upscale commercial space at street level, such as Safi and D'Oro Caffe.

The tower's main lobby consists of three stories, followed by the Park Suites, which are condos customly furnished by the Rockwell Group, on floors 4 through 9.

The tower's architecture is based on the Miami Modern (abbreviated as MiMo) style, and has many design features that pay tribute to landscape architect Roberto Burle Marx's emphasis on natural aesthetics seen along the bay.

The site where 50 Biscayne stands today was formerly home to the Columbus Bazaar, a shopping mall which replaced The Hotel McAllister and the Columbus Hotel in a quick fix effort to reutilize the land when both establishments closed for business.