50 Years of Blonde on Blonde was recorded live at the CMA Theater at the Country Music Hall of Fame, in Nashville, Tennessee, in May 2016.

[2] The concert coincided with a Hall of Fame exhibit exploring Dylan's time in Nashville.

[3] In an interview, band members Ketch Secor and Critter Fuqua described how they had bonded over Dylan's songs as teenagers, and that the 50 Years... project was a natural extension of that collaboration.

[4] While the new recording follows the sequence of Dylan's original track-for-track, Old Crow took considerable liberties with the arrangement of individual tracks, for instance reimagining "Pledging My Time" as a "hillbilly breakdown," and "Obviously 5 Believers" as "a manic fiddle riot.

Old Crow Medicine Show undertook a planned 27-date tour in support of 50 Years... in May and June, 2017.