Its first credited aerial victory came on 1 February, a German Me 109 downed over Koy-Asan by a pair of MiGs led by Junior Lieutenant Menyak.

With the Crimean Front, the regiment flew 1,255 sorties mostly providing air cover to ground troops, with the loss of eight aircraft and six pilots.

After the Soviet defeat in the Battle of the Kerch Peninsula, the regiment handed over its remaining aircraft to the 25th IAP and went to the rear for replacements.

The regiment reorganized to consist of two squadrons with an authorized strength of 20 fighters and re-equipped with the LaGG-3 during June and July, under the 2nd Reserve IAP at Seyma, Gorky Oblast.

The regiment spent the rest of the war under the command of Vinokurov with the 315th IAD and was assigned to fly aerial photographic reconnaissance missions from May 1943.

The 50th IAP supported the Soviet advance into northern Belorussia towards Vitebsk and Polotsk in October, and the continued push to the west in the February 1944 Staraya Russa–Novorzhev offensive.

In late 1951, the division was transferred to the Air Forces of the North Caucasus Military District, moving to Maykop.

The regiment and its division returned to PVO control in July 1954 with their transfer to the North Caucasus Air Defence Army.