The 2001 National Hockey League All-Star Game took place on February 4, 2001, at Pepsi Center in Denver, home to the Colorado Avalanche.

Colorado Avalanche's Joe Sakic, Vancouver Canucks' Ed Jovanovski and Philadelphia Flyers' Simon Gagne teamed to win the puck control relay, while the Mighty Ducks of Anaheim's Paul Kariya would win his third-straight individual Puck Control Relay event.

Joe Sakic, Bill Guerin, and Los Angeles Kings' Luc Robitaille pot three goals in the inaugural pass and score competition.

Bill Guerin, Tony Amonte and Doug Weight played as an all-American line, combining for 13 points (six goals and seven assists).

In his All-Star Game debut, Guerin recorded a hat-trick and added two assists, capturing MVP honors.