The 52nd Ohio Infantry Regiment was organized at Camp Dennison near Cincinnati, Ohio in August 1862 and mustered in for three years service under the command of Colonel Daniel McCook, Jr.
The regiment was attached to 36th Brigade, 11th Division, Army of the Ohio, to October 1862.
36th Brigade, 11th Division, III Corps, Army of the Ohio, to November 1862.
2nd Brigade, 4th Division, Center, XIV Corps, Army of the Cumberland, to January 1863.
2nd Brigade, 2nd Division, Reserve Corps, Department of the Cumberland, to October 1863.
The 52nd Ohio Infantry mustered out of service at Washington, D.C., on June 3, 1865.
March to relief of General Nelson August 29 – September 1.
Escort ammunition trains to Stones River December 28–30, 1862.
March to Bridgeport, Ala., via Franklin, Columbia, Athens and Huntsville.
(Temporarily attached to 3rd Brigade, 2nd Division, XI Corps.)
Tunnel Hill, Buzzard's Roost Gap and Rocky Faced Ridge February 23–25.
Operations on line of Pumpkin Vine Creek and battles about Dallas, New Hope Church and Allatoona Hills May 25 – June 5.
Operations about Marietta and against Kennesaw Mountain June 10 – July 2.
Ruff's Station, Smyrna Camp Ground, July 4.