The area was originally high class residential, but now is mainly occupied by commercial premises.

Baker Street is a busy thoroughfare, lying in postcode areas NW1/W1 and forming part of the A41.

[citation needed] Residents of the prestigious mansion block, Chiltern Court on the Regent's Park end of Baker Street include the novelists Arnold Bennett and H. G. Wells who are commemorated with a blue plaque.

For many years the head office of Marks & Spencer, formerly the United Kingdom's largest retailer, was at "Michael House" (named in parallel with the group's "St Michael" brand), 55 Baker Street, until the company relocated to the Paddington Basin in 2004.

This was one of the best known corporate buildings in the United Kingdom, and has since been redeveloped as a modern office complex by London & Regional Properties[3] to a design by Make Architects and Expedition Engineering.

A London County Council blue plaque commemorates Prime Minister William Pitt the Younger who lived at 120 Baker Street from 1803 to 1804.