The group operated chiefly against strategic objectives in Germany until May 1945, flying 188 missions and losing 33 aircraft.

Targets included marshalling yards in Stuttgart, Cologne, and Mainz; airfields in Kassel and Münster; oil refineries and storage plants in Merseburg, Dollbergen, and Hamburg; harbours in Bremen and Kiel; and factories in Mannheim and Weimar.

Other missions included bombing airfields, gun positions, V-weapon sites (total of nine "No Ball" missions beginning 20 June),[3] and railway bridges in France in preparation for or in support of the invasion of Normandy in June 1944; striking road junctions and troop concentrations in support of ground forces pushing across France, July–August 1944; hitting gun emplacements near Arnhem to minimize transport and glider losses during the airborne invasion of the Netherlands in September 1944; and bombing enemy installations in support of ground troops during the Battle of the Bulge (December 1944 – January 1945) and the assault across the Rhine (March–April 1945).

The 586th Tactical Missile Group was activated at Hahn Air Base as part of the new 38th TMW and became the headquarters for the 405th TMS, the 586th MMS, and the 586th SS.

64 missiles that were to be assigned to the 486 TMW's Tactical Missile Squadrons—that would disperse to the field from their on base hardened shelter-secured GLCM Alert & Maintenance Area (GAMA) in OPCON threat warning conditions under its concept of operations, were supposed to be assigned, however, the wing did not actually receive operational missiles before beginning to phase down mission/base closure on 20 September 1988 and USAF personnel were reassigned to different bases and the (still under construction contracts) base was returned to the Dutch.

This article incorporates public domain material from the Air Force Historical Research Agency