The battalion left Providence for Annapolis, MD to join Burnside's expedition to North Carolina.

It was then posted at Newport City until the siege of and assault on Fort Macon, in which it was active, after which it went into camp at Bogue banks and later at Beaufort, SC.

Returning to New Berne the regiment reoccupied Camp Anthony and garrisoned Forts Totten and Rowan.

Attached to:[2] The official list of battles in which the regiment bore a part:[2] The regiment lost a total of 119 men during service (this includes casualties after it was changed to heavy artillery); 1 officer and 8 enlisted men killed or mortally wounded, 4 officers and 106 enlisted men died of disease.

[4][note 2] The 1856 Enfield was a .577 calibre Minié-type muzzle-loading rifle that like all other nominal .577 caliber weapons could fire U.S. government issued .58 paper cartridges.