During the International Geophysical Year 1957–1958, and subsequently through 1962 the wing supported scientific stations in the Arctic Ocean by airlanding and airdropping supplies on the drifting ice.

[2] In 1963 the wing assumed responsibility for worldwide airlift of nuclear weapons and associated equipment, continuing this mission through early 1971.

62 AW aircraft were also used that year to transport firefighters and supplies to Wyoming to fight major forest fires in Yellowstone National Park.

Additionally, during 1991, 62 AW personnel and aircraft facilitated the evacuation of Clark Air Base and Subic Bay Naval Station following the eruption of Mount Pinatubo in the Philippines.

During 1995, the 62 AW deployed personnel and aircraft to the U.S. Virgin Islands following Hurricane Marilyn and to Bosnia in support of Operation Joint Endeavor.

62 AW personnel delivered relief supplies to Ho Chi Minh City, Vietnam following torrential rains and flooding spawned by Typhoon Linda in 1997.

In 1998, the 62 AW delivered relief supplies to Guam following Super Typhoon Paka, to Papua New Guinea following a tsunami, to Changsha, China following severe flooding, and to Nairobi, Kenya following the bombing of the U.S. Embassy there.

In late 2004 and early 2005 the 62 AW was dispatched with emergency relief supplies to areas throughout Southeast Asia in response to the tsunami that struck on 26 December 2004.

On 8 May 2020, the 62 AW saluted the healthcare workers at the forefront in the fight against COVID-19 by performing a 2.5-hour C-17 Globemaster III two-ship formation flyover throughout Washington State's Puget Sound Region.