The film reveals multiple methods of assassination, from exploding cigars to femmes fatales; a radio station rigged with gaseous LSD to a poison syringe posing as an innocuous fountain pen.

The film also contains extensive material shot with Antonio Veciana, the Cuban exile who came close to killing Castro on three occasions over 17 years.

Other characters are Cuban exile Félix Rodríguez, the CIA operative who trained Cuban exiles for the Bay of Pigs Invasion, and who was present when the Bolivian Army killed Che Guevara in 1967 at the request of the Bolivian President at the time, and Enrique Ovares, possibly the first man to make an attempt on Castro's life after he took power.

Robert Maheu is also interviewed, the Hughes associate who served as liaison between the CIA and mobsters "Johnny" Roselli and Sam "Momo" Giancana, in another plot to kill Castro, this time using poison pills.

She responded by asserting that the clip was spliced together and that it was taken out of context; but after her account was contested by the film's director, she eventually released a statement, on Christmas Eve, accepting that she had made the remark.