It was last active at Reese Air Force Base, Texas, where it conducted pilot training for twenty-five years before it was inactivated in September 1997.

The 64th Troop Carrier Wing was activated at Donaldson Air Force Base, South Carolina on 14 July 1952, taking over the personnel, mission and Fairchild C-82 Packets of the inactivating 375th Troop Carrier Wing, a reserve unit that had been called to active duty for the Korean War.

[1] The 64th was activated at Dyess Air Force Base, Texas on 8 February 1961 and began to organize with Lockheed C-130 Hercules aircraft.

Elements of the wing deployed to the Indian Ocean area to support NASA space missions.

[4] During the Cuban Missile Crisis, the wing flew 107 missions to support American forces, mostly in Florida.

[1][5] On 1 December 1965, in anticipation of the forthcoming move of the 314th Troop Carrier Wing to Taiwan, Tactical Air Command activated the Troop Carrier Wing, Provisional, 4413th at Sewart Air Force Base, Tennessee.

It was intended that these simulators would replace instrument flying training missions with the exception of validation flights.

Following a test at Williams Air Force Base, Arizona, second squadrons were activated In 1990 for the wing's T-37s and its T-38s.

[18] With the implementation of Joint Specialized Undergraduate Piot Training in 1993, three naval instructor pilots were assigned to the wing in September, while three of the wing's instructors were assigned to Naval Air Station Corpus Christi in December.

[20] In December 1993, the wing began the Introduction to Bomber Fundamentals course, training not only pilots, by also navigators and electronic warfare officers in crew coordination and low level flying procedures.

[24] This article incorporates public domain material from the Air Force Historical Research Agency