The 64th Annual Grammy Awards ceremony was held at the MGM Grand Garden Arena in Las Vegas on April 3, 2022.

[5] The nominations were announced during a virtual livestream on November 23, 2021, by Recording Academy CEO Harvey Mason Jr., alongside Jon Batiste, Billie Eilish, Finneas O'Connell, H.E.R., BTS, Måneskin, Tayla Parx, Carly Pearce, comedian Nate Bargatze, Recording Academy chair Tammy Hurt, and CBS Mornings anchor Gayle King.

[13] The Recording Academy subsequently honored Drake's request and officially removed his nominations for both awards.

On January 5, 2022, the Recording Academy postponed the ceremony indefinitely due to health and safety concerns related to the COVID-19 Omicron variant.

[16][17][18] Foo Fighters were announced as a performer on March 24, one day before the death of their drummer Taylor Hawkins.

[20] A tribute montage dedicated to Hawkins and set to "My Hero" was aired during the ceremony before the in memoriam segment.

Prior to the performance, a short video of Volodymyr Zelenskyy concerning the circumstances of warfare and military activity in Ukraine was played.

[26] The In Memoriam segment was introduced by host Trevor Noah, with Cynthia Erivo, Ben Platt, Leslie Odom Jr., and Rachel Zegler performing multiple songs by American composer Stephen Sondheim during the segment, including "Somewhere" (from West Side Story), "Send in the Clowns" (from A Little Night Music), and "Not a Day Goes By" (from Merrily We Roll Along).