[1][5] It deployed to the European Theater of Operations (ETO), where it was assigned to VIII Bomber Command in England during the summer of 1942.

A detachment deployed to the Twelfth Air Force in Algeria in June 1943 to help facilitate the Allied invasion of Sicily by bombing airfields and marshalling yards in Italy.

Most of the detachment returned to England at the end of August, however some crews and aircraft remained in the Mediterranean Theater of Operations and flew very long range attacks over Italy, Romania, Austria and Sicily and supported Allied ground forces in Sicily as well as attacking Axis forces in Italy opposing the Salerno landing.

The squadron returned to VIII Bomber Command operations, and supported the Allied Invasion of France in June 1944 by attacking strongpoints in the beachhead area and transportation targets behind the front line.

The squadron attacked airfields and transportation in support of the Western Allied Invasion of Germany, and flew a resupply mission during the airborne assault across the Rhine in March 1945.

The squadron was reactivated in 1947 under SAC as a paper unit; it was not manned or equipped and inactivated in 1949 due to budget constraints.

These machines were capable of flying at high subsonic speeds and primarily designed for penetrating the airspace of the Soviet Union.

During March 1965 the squadron was responsible for the missile that was launched from a November Flight LF, 10 miles north of Newell, South Dakota.

The squadron remained on Cold War nuclear alert until President Bush's directive to stand the Minuteman II down.

These crews worked together with the 28th Air Refueling Squadron, which operated several Boeing EC-135 variants to include the EC-135A, EC-135G, and EC-135L, all of which had ALCS equipment installed on board.

Download coordinates as: 44°08′42″N 103°06′13″W / 44.14500°N 103.10361°W / 44.14500; -103.10361 (Ellsworth AFB) This article incorporates public domain material from the Air Force Historical Research Agency