The 69th Regiment Illinois Volunteer Infantry was an infantry regiment that served in the Union Army during the American Civil War.

The 69th Illinois Infantry was organized at Camp Douglas at Chicago, Illinois and mustered into Federal service on June 16, 1862, for a term of three months.

The regiment was mustered out on September 27, 1862.

The regiment suffered 25 enlisted men who died of disease, for a total of 25 fatalities.

This article about a specific military unit of the American Civil War is a stub.