In autumn 1912 it served under Colonel Konstantinos Miliotis-Komninos during the Balkan Wars.

In autumn 1916, the Serres Division (Μεραρχία Σερρών) was formed by the Provisional Government of National Defence as its first major military formation, and was sent to the Macedonian front.

The division fought in the Asia Minor Campaign and the Greco-Italian War.

In was reformed in 1946 from the 25th, 26th and 27th Brigades as part of the III Army Corps.

In the period 1960–1998 the division came under the II Army Corps.