It was a part of the famed Michigan Brigade, commanded for a time by Brigadier General George Armstrong Custer.

Among the officers who later joined the regiment as replacements were Thomas W. Custer, who would earn two Medals of Honor while serving with the 6th in the spring of 1865.

The regiment was assigned to what became the Michigan Brigade during the early part of the Gettysburg Campaign in June 1863.

Sent out to the Old West frontier following the cessation of hostilities in mid-1865, the 6th, commanded by Colonel James H. Kidd and under the overall command of Brigadier General Patrick Connor constructed "Fort Connor" as a supply depot during the Powder River Expeditions of that summer.

This article about a specific military unit of the American Civil War is a stub.