In 1864, eleven of the regiment's twelve companies were part of Lieutenant Colonel Samuel M. Pollock's 1st Brigade of Brigadier General Alfred Sully's District of Iowa.

The regiment was mustered out of Federal service on October 17, 1865.

A total of 1420 men served in the 6th Iowa at one time or another during its existence.

[1] It suffered 1 officer and 21 enlisted men who were killed in action or who died of their wounds and 1 officer and 74 enlisted men who died of disease, for a total of 97 fatalities.

This article about a specific military unit of the American Civil War is a stub.