Deployed to the European Theater of Operations (ETO) in late 1943 and assigned to IX Fighter Command, Ninth Air Force.

Initial Mission of the Wing was to receive operational orders from Headquarters, IX Fighter Command and direct subordinate groups in attacking enemy targets in Occupied France and the Low Countries in preparation for the Normandy Invasion in June 1944.

After the D-Day invasion, was reassigned to IX Tactical Air Command (IX TAC) and directed to provide ground support for advancing United States First Army forces in France, attacking enemy targets initially in the Cotentin Peninsula, then supported Operation Cobra, the breakout of Normandy and attacked enemy forces in the Falaise-Argentan Gap.

In December 1944/January 1945, engaged enemy targets on the north side of the Battle of the Bulge, then moved eastward into the Northern Rhineland as part of the Western Allied invasion of Germany.

First Army halted its advance at the Elbe River in late April 1945, the wing engaging targets of opportunity in enemy-controlled areas until combat was ended on 5 May 1945.