According to British historian Mark Axworthy, the gun could be considered the most versatile of its class developed during World War II, outperforming Soviet, German and Western counterparts.

To speed development Colonel Valerian Nestorescu suggested combining the best features from the 75 mm (3.0 in) guns already in service in Romania, Germany or captured from the Soviets.

1100 guns were ordered on 10 December 1943 from Uzinele și Domeniile Reșița, Astra in Brașov and Concordia in Ploiești.

The 75 mm Reșița Model 1943 had a maximum elevation angle of 35 degrees, which allowed it to also be employed as a field gun.

This made the Romanian gun arguably the most versatile in its class during World War II, outperforming its Western, German and Soviet equivalents.

Despite the losses suffered during the Soviet Jassy-Kishniev Offensive of August 1944 most divisions at the front in February 1945 had between six and twelve 75 mm Reșița Model 1943 on hand.

An almost complete example, lacking optical sights, is displayed at the Romanian National Military Museum in Bucharest.