[1] The house, in Collegiate Gothic Revival style, was built in 1920, designed by Edwin Kline, and originally served as a medical office.

[4] When Rabbi Menachem Mendel Schneerson arrived from Vichy France to New York in 1941, his father-in-law appointed him as chairman of Merkos L'Inyonei Chinuch.

After Yosef Yitzchok's passing in January 1950, his son-in-law and successor, Menachem Mendel Schneersohn, continued to use his own office on the main floor to lead the movement, while maintaining his personal residence on President Street, several blocks away.

Her two daughters would often visit her in her apartment, and during her lifetime the new Rebbe would conduct semi-private meals there for the family and selected visitors on festive occasions.

[8] As the Lubavitch movement grew in the United States, the original synagogue became too small to house the chasidim and students who came to pray and study there.

On December 9, 2014, a little after 1:00 am, an individual with a documented history of mental health issues entered a synagogue and assaulted a student with a knife.

[14] Though a court ruling in 2006 decided that full ownership of 770 belongs to Agudas Chasidei Chabad, ongoing legal disputes have prevented either party from altering the structure.

[14] In December 2023, an unauthorized underground digging was discovered connecting the main synagogue to a nearby unused mikveh.

[5] In response, Chabad leadership closed the women's balcony on the floor above until the tunnel could be filled in[16] and called in construction crews to flood the expansion with concrete.

The Yeshiva is a part of a group of Yeshivot called Tomchei Tmimim, started by the 5th Chabad Rebbe Sholom Dovber Schneersohn of Lubavitch.

[24] Other replicas include UCLA Chabad House at UCLA Los Angeles, California; Moshiach Center In Fort Lauderdale Fl, Chabad House at Rutgers University in New Brunswick, New Jersey; Congregation Ahavat Shalom in Ocean City, Maryland; in Los Angeles, California; in St Kilda East, Victoria, a suburb of Melbourne, Australia; in Milan, Italy; in Brazil; in Argentina; in Chile, in Kamianske, Ukraine; in Camp Gan Israel in Montreal, Quebec and most recently in Baltimore, Maryland.