The regiment primarily operated in Kentucky, Tennessee, and western North Carolina, seeing action in several campaigns and cavalry raids as part of the Army of the Ohio.
[1] Participating in the Knoxville Campaign in the autumn of 1863, the regiment suffered a significant setback in a small skirmish in Greeneville, Tennessee, on November 6.
[2] In July 1864, the regiment moved from Tennessee into Georgia and joined the forces of Maj. Gen. William T. Sherman during the Atlanta Campaign.
It participated in numerous skirmishes and engagements with Confederate cavalry until the fall of Atlanta in late July.
It pursued retreating Confederates as far as the Andersonville Prison in Georgia, where news was received that Robert E. Lee had surrendered in Virginia.